Flash Nanoprecipitation: Prediction and Enhancement of Particle Stability via Drug Structure
نویسندگان
چکیده
منابع مشابه
Flash Nanoprecipitation: Prediction and Enhancement of Particle Stability via Drug Structure
Flash nanoprecipitation (FNP) can generate hydrophobic drug nanoparticles in ∼ 100 nm with a much higher drug loading (e.g., > 40 wt %) than traditional nanocarriers (e.g., < 20 wt %). This paper studies the effects of drug molecules on nanoparticle stability made via FNP and demonstrates that chemically bonding a drug compound (e.g., paclitaxel) with a cleavable hydrophobic moiety of organosil...
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ژورنال
عنوان ژورنال: Molecular Pharmaceutics
سال: 2014
ISSN: 1543-8384,1543-8392
DOI: 10.1021/mp500025e